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Robert H Shoemaker Selected Research

Werner Syndrome Helicase

9/2013Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
1/2011Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.

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Robert H Shoemaker Research Topics

Disease

55Neoplasms (Cancer)
06/2022 - 03/2002
10Hypoxia (Hypoxemia)
12/2009 - 08/2002
9Neoplasm Metastasis (Metastasis)
12/2021 - 10/2005
7Breast Neoplasms (Breast Cancer)
01/2020 - 09/2007
5Colorectal Neoplasms (Colorectal Cancer)
12/2021 - 11/2006
5Colonic Neoplasms (Colon Cancer)
09/2011 - 11/2006
4Lung Neoplasms (Lung Cancer)
01/2021 - 07/2002
3Genomic Instability
06/2022 - 01/2009
3Infections
01/2022 - 11/2008
3Carcinogenesis
01/2021 - 12/2009
3Carcinoma (Carcinomatosis)
12/2008 - 07/2002
3Glioma (Gliomas)
09/2008 - 08/2002
2COVID-19
01/2022 - 09/2021
2Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer)
10/2021 - 01/2021
2Fibrosis (Cirrhosis)
11/2020 - 08/2011
2Leukemia
06/2017 - 07/2010
2Lymphoma (Lymphomas)
06/2017 - 03/2009
2Ataxia Telangiectasia (Louis Bar Syndrome)
09/2013 - 12/2009
2Werner Syndrome (Werner's Syndrome)
09/2013 - 01/2011
2Fanconi Anemia (Fanconi's Anemia)
09/2013 - 01/2011
2Clear Cell Sarcoma
11/2012 - 07/2010
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
07/2010 - 09/2007
2Alveolar Soft Part Sarcoma
08/2009 - 01/2008
1Malignant Mesothelioma
06/2022
1Microsatellite Instability
06/2022
1Chromosomal Instability (Chromosome Stability)
11/2021
1Weight Loss (Weight Reduction)
09/2021
1Liver Cirrhosis (Hepatic Cirrhosis)
11/2020
1Hepatocellular Carcinoma (Hepatoma)
11/2020
1Precancerous Conditions
11/2020
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2020

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
11/2012 - 02/2004
10VaccinesIBA
12/2021 - 02/2016
9Pharmaceutical PreparationsIBA
01/2020 - 03/2002
7Biomarkers (Surrogate Marker)IBA
12/2021 - 09/2007
7DNA (Deoxyribonucleic Acid)IBA
09/2013 - 10/2005
5Transcription Factors (Transcription Factor)IBA
11/2012 - 10/2005
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2011 - 01/2008
4Naproxen (Naprosyn)FDA LinkGeneric
10/2021 - 01/2020
4Phosphotransferases (Kinase)IBA
03/2012 - 09/2006
4Topotecan (Hycamtin)FDA LinkGeneric
08/2009 - 02/2004
3AerosolsIBA
01/2022 - 01/2021
3CateninsIBA
12/2021 - 02/2011
3RNA (Ribonucleic Acid)IBA
01/2021 - 01/2009
3CarcinogensIBA
01/2021 - 09/2019
3AntigensIBA
11/2019 - 07/2002
3A-Form DNA (A-DNA)IBA
09/2013 - 10/2004
3Checkpoint Kinase 2IBA
12/2011 - 01/2009
3Messenger RNA (mRNA)IBA
09/2011 - 11/2006
3Bevacizumab (Avastin)FDA Link
08/2009 - 01/2008
3PoisonsIBA
10/2004 - 02/2004
3Type I DNA Topoisomerases (Topoisomerase I)IBA
10/2004 - 02/2004
2KininsIBA
01/2022 - 09/2021
2AngiotensinsIBA
01/2022 - 09/2021
2ReninIBA
01/2022 - 09/2021
2Peptides (Polypeptides)IBA
10/2021 - 11/2019
2Protein Subunit VaccinesIBA
01/2021 - 10/2017
2hydroxide ionIBA
01/2020 - 10/2018
2Werner Syndrome HelicaseIBA
09/2013 - 01/2011
2Threonine (L-Threonine)FDA Link
02/2012 - 10/2011
2polypeptide 3 90kDa ribosomal protein S6 kinaseIBA
09/2011 - 09/2006
2Calcium-Binding ProteinsIBA
09/2011 - 07/2011
2SolventsIBA
07/2011 - 03/2009
2LuciferasesIBA
07/2011 - 08/2002
2Oxygen (Dioxygen)IBA
12/2009 - 08/2006
2AntibodiesIBA
08/2009 - 01/2008
2Antineoplastic Agents (Antineoplastics)IBA
12/2008 - 09/2007
2ElementsIBA
10/2005 - 08/2002
1AsbestosIBA
06/2022
1MMEIBA
06/2022
1Immunomodulating AgentsIBA
12/2021
1ChromatinIBA
11/2021
1MicroRNAs (MicroRNA)IBA
01/2021
1Papillomavirus Vaccines (HPV Vaccines)IBA
01/2021
1Immune Checkpoint ProteinsIBA
01/2021
1Small Cytoplasmic RNAIBA
01/2021
1Neoplasm Antigens (Tumor Antigens)IBA
11/2020
1Cancer VaccinesIBA
11/2020
1Immune Checkpoint InhibitorsIBA
11/2020
1Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2020
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2020
1Atorvastatin (Lipitor)FDA Link
01/2020
1Metformin (Glucophage)FDA LinkGeneric
01/2020
1Cyclin D1IBA
01/2020
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
01/2020
1Progesterone Receptors (Progesterone Receptor)IBA
01/2020
1TamoxifenFDA LinkGeneric
01/2020
1vorozoleIBA
01/2020
1Bexarotene (LGD1069)FDA Link
01/2020
1Gefitinib (Iressa)FDA Link
01/2020
1Estrogen ReceptorsIBA
01/2020
1avasimibeIBA
11/2019
1Combined VaccinesIBA
11/2019
1Granzymes (Granzyme)IBA
11/2019

Therapy/Procedure

14Therapeutics
09/2021 - 08/2002
3Immunotherapy
01/2021 - 11/2017
2Chemoprevention
01/2021 - 10/2018
2Drug Therapy (Chemotherapy)
01/2008 - 10/2006
1Nebulizers and Vaporizers (Inhaler)
01/2022
1Intranasal Administration
09/2021